The ACE inhibitor lisinopril inhibits the conversion of angiotensin into nitric oxide. Losartan is an angiotensin II receptor blocker. A blood vessel’s tightening and relaxing functions are controlled by the renin-angiotensin system, which produces hormones. High blood pressure is caused by angiotensin II, a hormone that causes blood vessel constriction. The body cannot make angiotensin II when Lisinopril is taken. By preventing angiotensin II from binding to receptors, losartan and other ARBs lower blood pressure. Blood vessels do not narrow as a result of blocking angiotensin II’s message, which makes it harder for blood to flow through them, thus making the heart work harder for a longer period of time. The treatment of high blood pressure with lisinopril and losartan is similar, as they both reduce angiotensin II’s effects. However, there are a few key differences